Tier
S-tier
Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Quote
"On-demand air strike"
Effects
- Isaac's tears are replaced with guided missiles.
- Missiles deal 20 times Isaac's damage.
Synergies
- 20/20 - Fires a barrage of missiles.
- Mutant Spider - Fires a barrage of missiles.
- The Inner Eye - Fires a barrage of missiles.
- Blood Clot - Each missile has a 50% chance to deal 20 or 40 points more damage, respectively.
- Chemical Peel - Each missile has a 50% chance to deal 20 or 40 points more damage, respectively.
- Bob's Curse - Missiles gain a poison effect.
- Scorpio - Missiles gain a poison effect.
- Brimstone - Missile explosions shoot ten blood lasers in all directions.
- Butt Bombs - Missile explosions will cloud up the screen, briefly confusing and dealing 10 damage to all enemies in the room.
- Fire Mind - Missile explosions leave behind a fire that damage enemies on contact. Fire Mind's burn effect is overriden.
- Hot Bombs - Missile explosions leave behind a fire that damage enemies on contact. Fire Mind's burn effect is overriden.
- Glitter Bombs - Missile explosions have a small chance of spawning pickups.
- Host Hat - Isaac becomes immune to his own airstrikes.
- Pyromaniac - Isaac becomes immune to his own airstrikes.
- Ipecac - Missiles have a poison effect, have a larger blast radius and deal drastically increased damage, as the +40 damage from Ipecac is run through the damage multiplier of Epic Fetus.
- Mom's Knife - Missile explosions shoot a ring of ten knives.
- Monstro's Lung - 2 to 4 additional crosshairs orbit the main crosshair, and missiles are fired onto each crosshair.
- Mysterious Liquid - Every missile explosion leaves a small, lasting pool of creep.
The pool of creep left by the explosion is larger. - Polyphemus - Increased tear delay, but massively increases the missiles' blast radius and damage, as Polyphemus' damage multiplier is run through the damage multiplier of Epic Fetus.
- Sad Bombs - Missile explosions fire ten tears in all directions. The shrapnel's damage is not run through the damage multiplier of Epic Fetus.
- Strange Attractor - Enemies get drawn towards the crosshair.
- Technology - Both fire normally. Missile explosions shoot ten Technology beams in all directions.
- Tech X - Missile explosions shoot ten Technology beams in all directions.
Found in
- Treasure Room
- Secret Room
- Treasure Room (Greed Mode)