Cricket's Body - Split tears do half the damage of normal tears.
The Parasite - Split tears do half the damage of normal tears.
Godhead - Charging the shots increase the size and damage of the aura.
Haemolacria - Increased tear delay. Completely charged shots and their burst tears are larger and deal higher damage than normal. Chocolate Milk also allows low-damage Haemolacria shots to be fired rapidly.
Isaac's Tears - The size and damage of all generated tears correspond to the current charge level of Chocolate Milk. Isaac's Tears will nearly instantly recharge while charging a Chocolate Milk shot.
Sad Bombs - The size and damage of all generated tears correspond to the current charge level of Chocolate Milk. Isaac's Tears will nearly instantly recharge while charging a Chocolate Milk shot.
Tammy's Head - The size and damage of all generated tears correspond to the current charge level of Chocolate Milk. Isaac's Tears will nearly instantly recharge while charging a Chocolate Milk shot.
Ipecac - Increased tear delay. Charged shots deal massively increased damage, as the +40 damage from Ipecac is run through the damage multiplier of Chocolate Milk. It also allows low-damage Ipecac shots to be fired rapidly.
Lachryphagy - Rapidly firing small, uncharged tears can cause the fed tear to grow into a gigantic tear that will still deal fairly low damage while feeding tears with charged tears will result in higher-damage tears.
Polyphemus - Increased tear delay. Massively increases the damage of each shot, and charged tears decay in damage much slower as a result.
Sinus Infection - Booger damage is influenced by the damage of the individual tear, so fully-charged Chocolate Milk shots can result in very potent damage over time.
Technology 2 - Damage dealt by the laser is equal to Isaac's current charge, leading to constant high damage from a safe distance.
The laser deals 20% of Isaac's damage regardless of charge, tears are affected by Chocolate Milk as normal.
Trisagion - Fully charged beams deal four times normal damage. Trisagion's shots are colored brown.