The Binding of Isaac Wiki

Lost Soul

Lost Soul


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Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items.


"Protect him"


  • Gives Isaac a small soul that closely follows behind him. If the soul takes damage, it dies, respawning at the start of the next floor.
  • If the soul survives to the start of the next floor, it spawns one of the following:
    • 3 soul hearts.
    • 2 eternal hearts.
    • An item from the Treasure Room or Angel Room item pool.


Found in

  • Baby Shop
  • Secret Room
  • Treasure Room
  • Treasure Room (Greed Mode)


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