Tier
No votes yet
Upon entering a room, grants a shield that negates the first damage taken.
Quote
"Holy shield"
Effects
- Protects Isaac from damage by blocking one hit.
- Shield effect recharges the next room.
- This item belongs to the Seraphim set. Collecting three items from this set will transform Isaac into an angel.
Synergies
- E Coli - The nullified first hit will turn the contacted enemy into poop without damaging Isaac.
- Infamy - Infamy's chance of blocking projectiles is applied before the Holy Mantle, allowing the Holy Mantle hit to be saved.
- Isaac's Heart - The shield effect transfers to the heart.
- Midas' Touch - The nullified first hit will freeze and turn enemies into gold.
- Paschal Candle - The nullified first hit will not reset the tears bonus.
- Stop Watch - If damage is blocked with Holy Mantle, Stop Watch will trigger the slow effect.
Found in
- Angel Room
- Treasure Room
- Angel Room (Greed Mode)