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Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Demon Baby for the room instead.
Quote
"Double your friends"
Effects
- Upon use, it adds one copy of each of Isaac's familiars for the duration of the current room.
- If Isaac has no familiars, a Demon Baby will spawn for the duration of the current room.
Synergies
- Bob's Brain - When used upon entering a room, Box of Friends eliminates the item delay, which allows Isaac to launch Bob's Brain immediately.
- Car Battery - Adds two copies of each familiar.
- Cube of Meat - Upgrades the cube/ball for the current room. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements.
- Ball of Bandages - Upgrades the cube/ball for the current room. This can be used to easily unlock the Super Meat Boy and Bandage Girl achievements.
- Daddy Longlegs - Familiar will be copied.
- Incubus - Creates additional Incubus familiars, which share the same tear modifiers as the player.
- Multidimensional Baby - Each copy of Multidimensional Baby follows the previous copy with a 2.5-second delay.
- Smart Fly - Very useful on Greed mode, as using it will add an attacking fly, killing enemies and bosses very quickly.
Found in
- Crane Game
- Shop
- Treasure Room (Greed Mode)