Anti-Gravity - Tears that are floating in the air when they hit the prism will quadruple but will not move. Tears that begin moving before they hit the prism will travel outwards normally. By releasing the built up tears as the prism passes by, significantly more tears can be affected than normal.
Tractor Beam - Tears will split but continue stacked on top of each other along the tractor beam, essentially quadrupling the shot's damage.
Duct Tape - By keeping the prism in the same spot, damage output can be significantly increased in that direction. Duct Tape + Incubus: By stacking the incubus familiar on top of the prism before picking up Duct Tape, the shots will be affected no matter what direction Isaac is firing.
Immaculate Heart - The extra spectral tears generated will almost certainly hit the prism as they share the same orbit.