When picked up, all future items become "Glitched", causing them to become random combinations of 2-3 effects based on other items.
Additionally, the currently playing music will fade out. The silence will remain until another music track plays.
"Glitched" items can be passive or active and are completely randomly generated with nearly infinite possibilities.
Random effects combine effects that exist on other items, and assign them to a random event (e.g. on enemy death, on room clear, on damage taken etc.).