Swap between active items by pressing the Control key (PC), R2 (PlayStation), RT (Xbox), or ZR (Nintendo Switch).
Kamikaze! - The cooldown before the player can use Kamikaze! again is eliminated when switching items. Depending on how fast the player can push the buttons, Kamikaze! can be used multiple times during Isaac's invincibility frames.
Mom's Box - If a trinket is picked up while Mom's Box is in the active slot, swapping between active items will not remove the doubled trinket effect.
A Pony - Will continue to grant flight and the speed bonus while held in the secondary slot.
White Pony - Will continue to grant flight and the speed bonus while held in the secondary slot.