If a room gives a reward when cleared, there will be two different rewards to chose from. Taking one causes the other to disappear.
Quote
"There might be options"
Effects
Upon completing a room, if a room clear reward would spawn, another, different reward spawns next to it. If Isaac takes/opens one, the other disappears.
Synergies
Magneto - Opening a chest does not make the other reward disappear. Picking up the other reward afterwards will only remove the empty chest, and picking up the contents of the chest will not make the other reward disappear, letting Isaac take both rewards. This does not apply to chests with items in them, which disappear or make the other reward disappear as normal.
Deep Pockets - If multiple coins are generated, each one will have its own alternative reward.