Grants a 1/3 chance of replacing a room clear award with a normal chest or a locked chest, but also a 1/3 chance to replace it with nothing at all.

The effect does not apply to coins dropped in in Greed Mode.

This item belongs to the Guppy set. Collecting three items from this set will transform Isaac into Guppy.

The Left Hand - Turns all chests into Red Chests, allowing you to get Red Chest items much more quickly (including Guppy items).

Mom's Key - Increases the number of drops from chests and counteracts the increased chance to run into Locked Chests.

Room clear awards have a 1/3 chance of being replaced with a chest and a 1/3 chance being replaced with nothing.

The Binding of Isaac Wiki

Guppy's Tail