Genesis

Removes all of Isaac's items and pickups and takes him to a unique bedroom with some pickups and chests and a trapdoor to the next floor. For every item Isaac lost, he gets to take an item from a set of three.

Quote

"In the beginning"

Effects

• On use, the character, including stats and initial items, is reset and teleported to a unique Bedroom that acts like an I AM ERROR room. It has a Bed, two random Chests, two Sacks, and a random Trinket. The only way out is through the beam of light.
• For every item removed using Genesis, there will be a set of three items from the removed item's pool to choose from, each set appearing one after the other.
• • If you have multiple copies of an item being removed, the amount of extra choices you get is how many copies of that item you have squared. (4 of the same item -> 16 choices in Genesis)
• If used on one of the final floors of the game, such as Chest, the beam of light will be replaced with a crawl space that leads Isaac back to the starting room of the floor he used it on.

Found in

• Angel Room
• Angel Room (Greed Mode)